De-escalation Without Compromise: Practical Strategies for Community Oncologists
De-escalation Without Compromise: Practical Strategies for Community Oncologists

Drs. Shahid S. Ahmed and Jordan Ciuro discuss bridging access gaps between academic and community practices treating metastatic and localized prostate cancer, emphasizing strategies like short-term ADT, careful dose adjustments, and early incorporation of radiation therapy to support treatment de-escalation in resource-limited settings.

They also stress the importance of improving communication with community providers, ensuring adherence to doublet therapy when appropriate, and prioritizing quality of life through thoughtful, individualized treatment planning while awaiting more definitive trial data.

Latest News

Phase 2b SunRISe-1 Results: Outcomes of TAR-200 in Patients With BCG-Unresponsive NMIBC
Phase 2b SunRISe-1 Results: Outcomes of TAR-200 in Patients With BCG-Unresponsive NMIBC
Jessica GangaNon-Muscle Invasive Urothelial Carcinoma | August 15, 2025
TAR-200 alone was compared with TAR-200 in combination with a PD-1 inhibitor to determine the efficacy of the treatment.
The Future of Prostate Cancer Care: Toward a Cure and Personalized Medicine
The Future of Prostate Cancer Care: Toward a Cure and Personalized Medicine
Mark Delworth, MDProstate Cancer | August 14, 2025
The panel concludes with a discussion on the future of prostate cancer treatment, emphasizing the pursuit of cures.
Integrating Lutetium-177, Precision Medicine in Advanced Prostate Cancer Care
Integrating Lutetium-177, Precision Medicine in Advanced Prostate Cancer Care
Mark Delworth, MDProstate Cancer | August 14, 2025
The panel transitions to the evolving use of Lutetium-177, including from a post-chemo to a pre-chemo indication.
Managing Side Effects and Timing of Radium-223, PARP Inhibitors
Managing Side Effects and Timing of Radium-223, PARP Inhibitors
Mark Delworth, MDProstate Cancer | August 14, 2025
The panel considers the use of radium-223, PARP inhibitors, and other therapies for patients with mCRPC.
Evolving Treatment Paradigms: From Oligometastatic Management to Combination Therapies
Evolving Treatment Paradigms: From Oligometastatic Management to Combination Therapies
Mark Delworth, MDProstate Cancer | August 14, 2025
The panel highlights the management of oligomets and the process for targeting small-volume mets to delay progression.
From Scans to Strategy: Imaging and Risk Assessment in Advanced Prostate Cancer
From Scans to Strategy: Imaging and Risk Assessment in Advanced Prostate Cancer
Mark Delworth, MDProstate Cancer | August 14, 2025
The panel discusses imaging and early indicators of disease progression in metastatic castration-sensitive prostate cancer.
Barriers and Benefits of Germline Testing in Prostate Cancer Care
Barriers and Benefits of Germline Testing in Prostate Cancer Care
Mark Delworth, MDProstate Cancer | August 14, 2025
The panel explores the role of germline and somatic genetic testing in managing metastatic CSPC.
Interlesional Tumor Response Can Identify Patients With mCRPC With Worse Outcomes After ARPI Therapy
Interlesional Tumor Response Can Identify Patients With mCRPC With Worse Outcomes After ARPI Therapy
Emily MenendezCRPC | August 13, 2025
A recent study evaluated the role of PSMA PET/CT in determining patient outcomes based on global tumor response.
Globalizing the Breakthroughs: The Next Chapter in Hereditary Kidney Cancer
Globalizing the Breakthroughs: The Next Chapter in Hereditary Kidney Cancer
Sandeep Gurram, MDnccRCC | August 13, 2025
Drs. Gurram and Yerram conclude with a discussion on the importance of multidisciplinary care for hereditary kidney cancer.
Metabolism Meets Medicine: A New Era for Hereditary Kidney Cancer Treatment
Metabolism Meets Medicine: A New Era for Hereditary Kidney Cancer Treatment
Sandeep Gurram, MDnccRCC | August 13, 2025
Drs. Gurram and Yerram review options for hereditary kidney cancers, highlight data on bevacizumab plus erlotinib, anlotinib.
Validating the Use of the GRANT Score as a Prognostic Tool for Patients With Papillary RCC
Validating the Use of the GRANT Score as a Prognostic Tool for Patients With Papillary RCC
Jessica GanganccRCC | August 12, 2025
Researchers aimed to validate the use of the GRANT score to predict the prognosis of patients with pRCC after surgery.
Risk Factors, Incidence of Arterial Thromboembolic Events in Patients With Germ Cell Tumors After Chemotherapy
Risk Factors, Incidence of Arterial Thromboembolic Events in Patients With Germ Cell Tumors After Chemotherapy
Jessica GangaTesticular, Penile, and Rare Malignancies | August 12, 2025
Researchers aimed to establish an association between ATEs and germ cell tumors to determine preventative strategies.
Editorial Advisory Board
Brian Rini, MD, FASCO
Brian Rini, MD, FASCOEditor | Chief of Clinical Trials at Vanderbilt-Ingram Cancer Center
Thomas Powles, MBBS, MRCP, MD
Thomas Powles, MBBS, MRCP, MDEditor | Director, Barts Cancer Centre at St. Bartholomew's Hospital
Katy Beckermann, MD, PhD
Katy Beckermann, MD, PhDEditor | Medical Director of GU Clinical Research at Tennessee Oncology
Christopher Wallis, MD, PhD, FRCSC
Christopher Wallis, MD, PhD, FRCSCAssistant Professor of Urology | University of Toronto
Akhil Abraham Saji, MD
Akhil Abraham Saji, MDEditor | Urologist at Swedish Health Services
David Ambinder, MD
David Ambinder, MDEditor | Urology Resident at New York Medical College/Westchester Medical Center

The Uromigos Live and Unplugged 2024

The Uromigos Live & Unplugged 2024
The Uromigos Live & Unplugged 2024

The Uromigos Live & Unplugged 2024 took place September 27-29 in Nashville, Tennessee.

This meeting was the third annual in-person event hosted by Thomas Powles, MD, and Brian Rini, MD, FASCO, in partnership with Mashup Media, featuring expert panels and audience discussion around the latest data in genitourinary oncology and vision for the future.

Expert Interviews

Teaching TURBT Over 5G: Integrating XR Headsets Into Urologic Practice
Teaching TURBT Over 5G: Integrating XR Headsets Into Urologic Practice
Evan Kovac, MDProstate Cancer | May 19, 2025
Dr. Evan Kovac speaks about his pioneering work with extended reality display technology in urologic surgery and education.
Bladder Cancer Without Cystectomy: Dr. Alexandre Zlotta on the Maturation of Trimodality Therapy
Bladder Cancer Without Cystectomy: Dr. Alexandre Zlotta on the Maturation of Trimodality Therapy
Alexandre Zlotta, MDMuscle Invasive Urothelial Carcinoma | May 15, 2025
Dr. Zlotta discusses the current state and future of bladder-sparing therapy in MIBC, including how to best select patients.
From VEGF to HIF-2 Targeting Drugs: Dr. James Brugarolas’ Journey to Transforming Kidney Cancer Treatment
From VEGF to HIF-2 Targeting Drugs: Dr. James Brugarolas’ Journey to Transforming Kidney Cancer Treatment
James “Jim” Brugarolas, MD, PhDRenal Cell Carcinoma | April 22, 2025
Dr. Brugarolas reflects on his lab's role in developing HIF-2 inhibitors and his ongoing work to improve patient outcomes.
Bladder-Sparing Innovations in MIBC: Dr. Elizabeth Plimack on the RETAIN Approach and Its Future
Bladder-Sparing Innovations in MIBC: Dr. Elizabeth Plimack on the RETAIN Approach and Its Future
Elizabeth Plimack, MD, MS, FASCOMuscle Invasive Urothelial Carcinoma | June 25, 2025
Dr. Plimack details RETAIN, from early findings with neoadjuvant ddMVAC to the evolution of RETAIN-1 and RETAIN-2.
Precision in Prostate Cancer: Dr. Amir Lebastchi on Tailoring Focal Therapy for Optimal Outcomes
Precision in Prostate Cancer: Dr. Amir Lebastchi on Tailoring Focal Therapy for Optimal Outcomes
Akhil Abraham Saji, MDLocalized | June 25, 2025
Drs. Saji and Lebastchi explore focal therapy, covering its historical evolution, techniques, and energy modalities.
Ahmed E. Ghazi – Revolutionizing and Scaling Surgical Training Through Simulation Models
Ahmed E. Ghazi – Revolutionizing and Scaling Surgical Training Through Simulation Models
David Ambinder, MDLocalized | June 25, 2025
Dr. Ghazi is recognized as a pioneer in patient-specific surgical simulation, using state-of-the-art techniques in surgery.

Knowledge Hubs

Curated clinical content based on conditions, therapies, and technologies

Prostate Cancer
Prostate Cancer
Localized
Localized
mHSPC/mCSPC
mHSPC/mCSPC
CRPC
CRPC
RLT
RLT
Prostate Cancer Diagnostics
Prostate Cancer Diagnostics
Renal Cell Carcinoma
Renal Cell Carcinoma
Localized Renal Cell Carcinoma
Localized Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
nccRCC
nccRCC
Renal Cell Carcinoma Diagnostics
Renal Cell Carcinoma Diagnostics
Urothelial Carcinoma
Urothelial Carcinoma
Non-Muscle Invasive Urothelial Carcinoma
Non-Muscle Invasive Urothelial Carcinoma
Muscle Invasive Urothelial Carcinoma
Muscle Invasive Urothelial Carcinoma
Advanced Urothelial Carcinoma
Advanced Urothelial Carcinoma
Upper Tract Urothelial Carcinoma
Upper Tract Urothelial Carcinoma
Urothelial Carcinoma Diagnostics
Urothelial Carcinoma Diagnostics
Testicular, Penile, and Rare Malignancies
Testicular, Penile, and Rare Malignancies
Prostate Cancer
Prostate Cancer
Localized
Localized
mHSPC/mCSPC
mHSPC/mCSPC
CRPC
CRPC

The Uromigos

Podcasts hosted by Professors Thomas Powles, MD, and Brian Rini, MD

Episode 434: IMPACT Series - A Walk Through the History of VEGF TKI Development in RCC
Episode 434: IMPACT Series - A Walk Through the History of VEGF TKI Development in RCC
Dr. Danny Heng joins the podcast to tour through VEGF TKI drug development from sorafenib to tivozanib.
# Posted on August 5, 2025
# Uromigos-Kidney Cancer
Episode 432: ASCO 2025 Rapid Oral Session RCC/Bladder Recap
Episode 432: ASCO 2025 Rapid Oral Session RCC/Bladder Recap
Dr. Karie Runcie joins the podcast to discuss insightful RCC and bladder presentations from ASCO 2025.
# Posted on July 23, 2025
# Uromigos-Bladder Cancer
# Uromigos-Kidney Cancer
Episode 431: IMPACT Series - Axel Bex on Impactful RCC Clinical Trials
Episode 431: IMPACT Series - Axel Bex on Impactful RCC Clinical Trials
Dr. Axel Bex discusses impactful RCC trials, consolidative approaches, and what can impact an academic career.
# Posted on July 17, 2025
# Uromigos-Kidney Cancer

Conference Coverage

Live meeting highlights

BCG, Biomarkers, and Beyond: GU Oncology Research and Treatment Advances
Sanjay Juneja, MDProstate Cancer | July 31, 2025
At the Oncology Forum, Dr. Sanjay Juneja led a dynamic discussion covering pivotal developments across genitourinary cancers.
View More
Prognostic Value of LuPSMA-SPECT/CT: Developing Clinical Protocols for Monitoring mCRPC Therapy
Loïc Djaileb, MD, PhDProstate Cancer Diagnostics | July 21, 2025
Dr. Loïc Djaileb explores the use of RECIP 1.0 criteria with SPECT/CT and the efficacy of this strategy in monitoring mCRPC.
View More
177Lu-PSMA: Single Time-Point Dosimetry Tied to Treatment Response in mCRPC
Valentina Marulanda Corzo, MDRLT | July 18, 2025
Drs. Tagawa and Marulanda Corzo discuss the use of single time-point SPECT/CT dosimetry for 177Lu-PSMA targeted RLT.
View More
When PSMA PET/CT Is Negative: Using 18F-Fluciclovine in Biochemical Recurrence of Prostate Cancer
Nadine Mallak, MDProstate Cancer Diagnostics | July 15, 2025
Dr. Nadine Mallak talks about 18F-fluciclovine to detect disease in BCR of prostate cancer when the standard of care fails.
View More

Video Insights

Clinical discussions with experts in the field

Network Websites

Blood Cancers Today provides hematologists and oncologists with news, education, and research relevant to their patients and practices. Featuring the latest clinical updates from all facets of the specialty, it offers thought-provoking insights and exclusive interviews from experts in the field.

MashupMD is an innovative medical news and social media aggregator. The platform is optimized to deliver rapid access to the latest headlines in health care and collections of key medical content based on what health care professionals around the world are reading and sharing.

Cancer Nursing Today delivers critical news, research, and commentary to support oncology nurses throughout their education and careers. Its goal is to advance oncology treatments and care practices and promote the nurse’s role in enhanced patient outcomes and quality of life.

DocWire News is a leading source of medical industry news for health care professionals, featuring breaking news, expert commentary, research analysis, and conference highlights. It covers a comprehensive range of clinical specialties, including cardiology, oncology, neurology, and more.

Urban Health Today is the leading independent news source that provides urban health care professionals with relevant research and policy developments that impact patients and their practices. Its coverage focuses on clinical, social, and environmental health disparities.

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GI Oncology Now is the leading medical news resource for practicing oncologists and health care providers treating gastrointestinal malignancies, offering the latest study data and research breakthroughs related to colorectal, gastric, liver, pancreatic, and esophageal cancers.

Heme Today produces the latest news and research for hematologists and oncologists focused on blood disorders such as clotting, red and white blood cell, and iron disorders, including conference highlights, late-breaking research, interviews with leaders in the field, and more.

A medical news property for practicing oncologists treating lung malignancies, Lung Cancers Today features breaking news, commentary, expert interviews, and data analysis to inform providers on the latest research and most effective clinical practices in the lung cancers space.

Nephrology Times delivers the latest news in nephrological treatments and technologies, curating content from clinical trials, conference highlights, and perspectives from key opinion leaders, with the goal of better informing care decisions and improving patient outcomes.

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