In patients with renal cell carcinoma (RCC), the appearance of positive surgical margin (PSM) has demonstrated a connection with higher risk of cancer-specific mortality (CSM) and recurrence. Previous studies investigating adjuvant therapy in patients with RCC have not included those with PSM. A recent study from Cesare Saitta, MD, and colleagues sought to determine the effects of PSM on the oncological outcomes of patients with nonmetastatic RCC undergoing treatment with adjuvant or neoadjuvant systemic therapy. ...