Renal Cell Carcinoma

15-Gene Signature Predicts RFS, DFS in Patients With ccRCC
To help risk stratify clear cell renal cell carcinoma (ccRCC), Rohit Mehra, MD, and colleagues developed a gene expression signature to predict recurrence-free survival (RFS) and disease-free survival (DFS) in this patient population. A discovery cohort was developed using 110 patients who had undergone radical nephrectomy for ccRCC. A 15-fold lasso and elastic-net regularized linear Cox model was used to develop the predictive gene expression signature. ...
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