Circulating tumor DNA (ctDNA) analysis can serve as a noninvasive alternative to tissue biopsy for genotyping in multiple forms of cancer. A recent study has sought to determine the clinical utility of ctDNA in advanced urothelial cancer (UC) by establishing and evaluating a plasma ctDNA sequencing assay. The study involved 82 patients diagnosed with muscle-invasive or metastatic UC, from which 158 blood samples and 73 tumors tissue samples were obtained and sequenced using the panel developed by the investigators, which included 53 UC-relevant genes as well as TERT promoter mutations. ...
Urothelial Carcinoma Diagnostics
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