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RLT
Radioligand therapy prostate-specific membrane antigen
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Radiopharmaceutical Trials in Prostate Cancer: Evolving Treatments and Combination Therapies
Robert Flavell, MD, PhD
RLT
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June 27, 2025
Dr. Flavell discusses how landmark studies have shaped current trial designs, and growing interest in combination therapies.
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Ongoing Radiopharmaceutical Therapy Trials in Prostate Cancer
Robert Flavell, MD, PhD
RLT
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June 27, 2025
Dr. Flavell highlights the expansion of lutetium PSMA therapies into earlier disease settings: HSPC and oligometastatic PC.
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Total Tumor SUVmean Robustly Predicts PSA PFS for Patients With mCRPC
Emily Menendez
RLT
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June 25, 2025
Quantitative analysis outperformed visual analysis in the prediction of outcomes for patients undergoing Lu-PSMA therapy.
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Monitoring [177Lu]Lu-PSMA Therapy in mCRPC: Clinical Protocols
Jessica Ganga
RLT
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June 25, 2025
New research explores the prognostic potential of LuPSMA-SPECT/CT with RECIP 1.0 in patients with advanced prostate cancer.
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EVOLUTION: Lu-PSMA With Ipi/Nivo in mCRPC
Scott Tagawa, MD, MS, FACP
RLT
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June 5, 2025
Dr. Tagawa explains the rationale for EVOLUTION, a phase II analysis of Lu-PSMA-617 with ipilimumab and nivolumab in mCRPC.
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TheraP: Clonal Hematopoiesis in mCRPC Patients Receiving Lu-PSMA or Cabazitaxel
Scott Tagawa, MD, MS, FACP
RLT
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June 5, 2025
Dr. Tagawa contextualizes a post hoc analysis on clonal hematopoiesis in those who received 177Lu-PSMA-617 or cabazitaxel.
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ProstACT GLOBAL: TLX591 and Best SOC for Patients With PSMA-Expressing mCRPC
Scott Tagawa, MD, MS, FACP
RLT
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June 5, 2025
Dr. Tagawa showcases the ProstACT Global trial, a phase III study of 177Lu-rosptamab in patients with mCRPC.
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VIOLET: Terbium-161 Radioligand Treatment in Patients With mCRPC
Scott Tagawa, MD, MS, FACP
RLT
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June 5, 2025
Dr. Tagawa breaks down the VIOLET study, a single-arm phase I/II first-in-human results of terbium-161Tb-PSMA-I&T.
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Cabazitaxel vs Lutetium-177: Efficacy for Metastatic Castration-Resistant Prostate Cancer
Zeynep Irem Ozay, MD
RLT
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June 4, 2025
Dr. Ozay discusses her study that compared the efficacy of cabazitaxel with lutetium Lu-177 in patients with mCRPC.
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BULLSEYE: Lu-PSMA in Oligometastatic HSPC
Bastiaan Privé, MD
RLT
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June 2, 2025
Drs. Privé and Tagawa discuss the BULLSEYE trial, an analysis of Lutetium-177-PSMA-617 in oligometastatic HSPC.
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ENZA-p: Predictive, Prognostic Value of Baseline PSMA Total Tumor Volume, SUV Mean
Louise Emmett, MD
RLT
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May 31, 2025
Louise Emmett, MD, discusses the ENZA-p trial which studied enzalutamide versus enzalutamide plus [177Lu] Lu-PSMA-617.
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Higher Progression-Free Survival Provided by LuPSMA Plus Ipi/Nivo Over LuPSMA Alone in Patients With mCRPC
Emily Menendez
RLT
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May 29, 2025
The addition of ipi/nivo to LuPSMA improved PSA-PFS over 12 months in patients with mCRPC.
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18F-Flotufolastat-PET Aids in Detection of Hematologic Malignancy in Patients With mCRPC Treated With 177Lu
Emily Menendez
RLT
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May 23, 2025
18F-flotufolastat-PET can help determine severe hematologic toxicity in patients with mCRPC who are treated with 177Lu.
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The Role of PSMA-Targeted Antibodies in Prostate Cancer
Scott Tagawa, MD, MS, FACP
Prostate Cancer
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April 4, 2025
Dr. Tagawa compares the use of PSMA-targeted antibodies to other treatment approaches such as radioligand therapy.
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PSMA RLT for Oligometastatic Prostate Cancer
Amar Kishan, MD
RLT
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April 3, 2025
Dr. Kishan reviews current evidence supporting the use of PSMA RLT in patients with oligometastatic disease.
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FDA Approves 177Lu Vipivotide Tetraxetan for PSMA+ mCRPC Treatment Before Chemotherapy
Emily Menendez
CRPC
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March 31, 2025
177Lu vipivotide tetraxetan is the only PSMA-targeted agent to significantly improve rPFS with a tolerable safety profile.
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Evaluating Safety and Efficacy of PSMA Therapy in the Castration-Sensitive Setting
Michael Morris, MD
mHSPC
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March 31, 2025
Dr. Morris discusses trials and rationale behind using PSMA therapy earlier in prostate cancer treatment.
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Improving Prostate Cancer Outcomes With Combination Therapy
Michael Hofman, MBBS, FRACP, FAANMS, FICIS, GAICD
RLT
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March 31, 2025
Dr. Hofman outlines promising PSMA combination therapies and emerging trials aiming to improve prostate cancer outcomes.
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PSMA and Beyond 2025: Reviewing the Agenda
Jérémie Calais, MD, PhD
RLT
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March 26, 2025
Dr. Calais provides an overview of this year's PSMA and Beyond conference agenda.
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ENZA-p Trial: Enzalutamide With [177Lu]Lu-PSMA-617 Improves OS in mCRPC
Emily Menendez
RLT
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March 7, 2025
Enzalutamide with [177Lu]Lu-PSMA-617 improved OS and HRQOL, along with PSA PFS.
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