A recent combined analysis of 2 phase 2 studies indicates that disitamab vedotin (DV) has promising efficacy and a manageable safety profile in patients with human epidermal growth factor receptor 2 (HER2)-positive locally advanced or metastatic urothelial carcinoma (UC) who had progressed on at least 1 line of prior systemic chemotherapy. The analysis was published in the Journal of Clinical Oncology. ...
Advanced Urothelial Carcinoma
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The FDA is granting a priority review for EV/pembro as well as nivo/chemo for the treatment of patients with la/mUC.
Dr. Nizam provides an overview of her recent research on biomarkers of TRAEs associated with EV for aUC.
The panel shares their hopes for the future of bladder cancer treatment.
The panel shares tips for community oncologists who may not be familiar with treating patients with EV/pembro.
The panel shares treatment sequencing decisions based on a few patient scenarios.
The panel discussed the double antibody-drug conjugate trial that assessed sacituzumab govitecan plus EV.
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Conference Coverage
Drs. Wallis and Sartor highlight issues with the control arm and considerations for treatment sequencing related to PSMAfore.
Dr. Sartor explains in detail the design and methodology, specific findings, nuances, and implications of the PSMAfore trial.
Drs. Joyce and Wallis consider the impact of financial toxicity and containing costs for patients with GU malignancies.
Drs. Pal and Wallis break down the role of the microbiome and response in patients with kidney cancer.
Dr. Prasad presented the results of the ENVISION trial assessing primary chemoablation in patients with LG-IR NMIBC.
Researchers sought to identify the frequency of germline mutations in patients 46 years or younger.