In the final segment, the panel emphasizes the importance of trust in the patient-provider relationship. The panel exchanges strategies on sequencing and debates the potential of immunotherapy in prostate cancer. In part four, the panel shares thoughts on the implications of recent trials including ARASENS, ARANOTE, and PEACE-3. The panel discusses nuances to consider when using PSMA PET imaging, including differentiating false positives. Experts discuss managing prostate cancer progression, risk stratification, and balancing treatment with quality of life. Expert panel discusses diagnostic criteria, precision medicine, and PSMA imaging in managing metastatic prostate cancer. The panel explores the distinct roles of alpha and beta emitters in radiopharmaceutical therapy for prostate cancer care. The expert panel discusses emerging biomarkers and treatment combinations for CRPC and mHSPC. The evolving role of RLT and radium-223 in managing metastatic mHSPC and CRPC is discussed. The panel examines the impact of the latest data from ARANOTE and PEACE-3 in part three of this roundtable. The panelists discuss key considerations for patient selection in doublet and triplet therapies for mHSPC and CRPC. In part one of this roundtable, the panel discusses advances in imaging and tailored treatment strategies for prostate cancer In part four of this roundtable series, the panelists discuss CRPC and the typical patterns of presentation. Part three of this roundtable delves into genomic biomarkers and the use of doublet and triplet therapies for mHSPC. Part two of the roundtable series explores ADT and novel hormonal therapies for patients with prostate cancer. Part one of a roundtable series on prostate cancer, focusing on defining mHSPC and mCRPC. Dr. Greenstein shares insights on the overall survival benefit of apalutamide over enzalutamide in a recent real-world study. Part five of this roundtable series covers data and insights from the ARANOTE and PEACE 3 trials. Part four of a PCa roundtable series focuses on the effectiveness of ADT with triplet therapy. Part three of this prostate cancer roundtable covers prognostic factors such as Gleason scores and genomic assays.