Dr. Silke Gillessen gives a summary of APCCC 2024, including surgery versus RT, genetic and somatic testing, and more. Chris Sweeney is joined by fellow experts to discuss mHSPC side effects such as bone weakness, hot flashes, and gynecomastia. Professor Thomas Suter and Dr. Chuck Ryan discuss cardiovascular risks associated with hormone therapy in prostate cancer. Drs. Thomas Zilli and Pierre Blanchard debate the use of radiation therapy in prostate cancer and oligometastatic disease. Brian and Tom speak with Drs. Piet Ost and Jason Efstathiou on the data for and against radiation therapy in prostate cancer. Daniel Goldstein returns to the podcast to discuss dosing changes in drugs such as nivolumab and pembrolizumab. FDA Deputy Oncology Director Dan Suzman describes approaches to oncology trials in the GU setting. Dr. Tanya Dorff discusses her work on a phase 1 study investigating acapatamab for advanced prostate cancer. Michael Lattanzi, MD, joins the podcast to discuss treatment plans and research in the community oncology setting. Vania Wisdom, Senior Executive Editor at The Lancet, discusses cancer treatment and research in developing countries. Dr. Dana Rathkopf describes the phase 1 data for the androgen receptor ligand-directed degrader in prostate cancer. Dr. Agarwal discusses the CONTACT-02 trial that analyzed the use of cabozantinib in combination with atezolizumab for mCRPC. Dr. Kim Chi discusses the BRCAAway and CONTACT-02 trials presented at ASCO GU 2024. Dr. Himisha Beltran, describes the activity of novel agent HPN328 in neuroendocrine prostate cancer. Neeraj Agarwal describes the results of the phase III CONTACT-02 trial on cabozantinib plus atezolizumab in prostate cancer.
... Karim Fizazi, MD, PhD, joins the show to discuss the phase III TALAPRO-2 trial published in Nature. Thomas Zilli joins the podcast to talk about the controversies surrounding radiotherapy for prostate cancer. Silke Gillessen and Betrand Tombal discuss the questions which will address this issue at APCCC 2024. Silke Gillessen gives an overview of APCCC 2024 taking place in Lugano, Switzerland, in April. The Uromigos close out the year with Tanya Dorff, MD, as she discusses her favorite prostate cancer studies of 2023.