Emily Menendez

GU Oncology Now

While nephrectomy is commonly used to treat kidney cancer, it can result in loss of kidney function or kidney failure in some patients. No tools to determine which patients may be at risk for kidney failure are currently available, and so <a href="https://www.ajkd.org/article/S0272-6386(23)00695-9/fulltext" target="_blank" rel="noopener">researchers developed a kidney cancer risk equation (KCRE) to predict the likelihood of kidney failure</a> after nephrectomy in patients with localized kidney cancer.Their study included a development cohort of 1026 patients with nonmetastatic kidney cancer who were treated with a partial or radical nephrectomy and had at least 1 estimated glomerular filtration rate (eGFR) measurement before and after nephrectomy. A separate validation cohort of 12,043 patients with localized kidney cancer who received a partial or radical nephrectomy and had at least 1 eGFR measurement before and after surgery was also included.The study&rsquo;s primary outcome was a composite of dialysis, transplantation, or an eGFR&#8197;under&#8197;15&#8197;mL/min/1.73&#8197;m2 during the follow-up period.An eGFR decline to less than 15 mL/min/1.73m2 occurred in 10.3% of patients in the development cohort, while 6.3% of patients in the validation cohort progressed to kidney failure. The KCRE model had a 5-year area under the curve of 0.85 in the development cohort and 0.86 in the validation cohort for predicting end-stage kidney disease.The KCRE model can be accurately applied in clinical practice to inform discussions about kidney failure risk in patients with localized kidney cancer, researchers concluded.

Predictive Model Identifies Patients Most at Risk for Kidney Failure After Nephrectomy

Localized Renal Cell Carcinoma

Researchers developed a kidney cancer risk equation to predict the likelihood of kidney failure after nephrectomy in patients with localized kidney cancer.

Predictive Model IDs Risk of Kidney Failure Post-Nephrectomy

About Us

Contributors and Partners

Editorial Policy

Advertising

eNewsletters

Calendar

Contact Us

Contribute

MashupMD

Cancer Nursing Today

Urban Health Today

Blood Cancers Today

DocWire News

Knowledge Hubs

Conference Coverage

Roundtables

The Uromigos

Uromigos Live 2024

AUC3

Localized

mHSPC/mCSPC

CRPC

Diagnostics

Prostate Cancer

Advanced Renal Cell Carcinoma

nccRCC

Renal Cell Carcinoma

Non-Muscle Invasive Urothelial Carcinoma

Muscle Invasive Urothelial Carcinoma

Advanced Urothelial Carcinoma

Upper Tract Urothelial Carcinoma

Urothelial Carcinoma

Testicular, Penile, and Rare Cancers

Video Insights

Advancements in Oncology

The Oncology Brothers

Expert Interviews

Journal

Subscribe